:root{
  --bg:#070b14;
  --bg-soft:#0c1322;
  --bg-alt:#0a1120;
  --panel:#111a2c;
  --panel-2:#16223a;
  --line:rgba(120,160,220,.14);
  --line-strong:rgba(120,160,220,.28);
  --ink:#eaf1fb;
  --ink-soft:#a9bad6;
  --ink-dim:#7488a8;
  --teal:#2fd6c4;
  --blue:#5b8cff;
  --violet:#a78bfa;
  --amber:#f5c451;
  --grad:linear-gradient(120deg,#2fd6c4 0%,#5b8cff 50%,#a78bfa 100%);
  --maxw:1140px;
  --r:18px;
  --shadow:0 20px 60px -25px rgba(0,0,0,.7);
}

*{box-sizing:border-box;margin:0;padding:0}
html{scroll-behavior:smooth;scroll-padding-top:84px}
body{
  font-family:'Inter',system-ui,sans-serif;
  background:var(--bg);
  color:var(--ink);
  line-height:1.65;
  -webkit-font-smoothing:antialiased;
  overflow-x:hidden;
}
a{color:inherit;text-decoration:none}
em{font-style:italic;color:var(--ink-soft)}
strong{color:var(--ink);font-weight:600}

#molecular-bg{
  position:fixed;inset:0;width:100%;height:100%;
  z-index:0;pointer-events:none;opacity:.55;
}

main,.site-header,.site-footer{position:relative;z-index:1}

/* ---------- HEADER / NAV ---------- */
.site-header{
  position:sticky;top:0;z-index:50;
  backdrop-filter:blur(14px);
  background:rgba(7,11,20,.72);
  border-bottom:1px solid var(--line);
}
.nav{
  max-width:var(--maxw);margin:0 auto;
  display:flex;align-items:center;justify-content:space-between;
  padding:14px 24px;gap:20px;
}
.brand{display:flex;align-items:center;gap:12px;font-weight:600;letter-spacing:-.01em}
.brand-text em{font-style:normal;color:var(--ink-dim);font-weight:500;font-size:.86em}
.brand-mark{
  width:26px;height:26px;border-radius:8px;flex:none;
  background:var(--grad);
  box-shadow:0 0 22px -4px var(--blue);
  position:relative;
}
.brand-mark::after{
  content:"";position:absolute;inset:6px;border-radius:4px;
  border:2px solid rgba(7,11,20,.85);
}
.nav-links{display:flex;gap:6px;list-style:none}
.nav-links a{
  padding:8px 14px;border-radius:10px;font-size:.93rem;color:var(--ink-soft);
  transition:color .2s,background .2s;
}
.nav-links a:hover{color:var(--ink);background:rgba(120,160,220,.08)}
.nav-toggle{display:none;background:none;border:0;cursor:pointer;flex-direction:column;gap:5px;padding:6px}
.nav-toggle span{width:24px;height:2px;background:var(--ink);border-radius:2px;transition:.25s}

/* ---------- HERO ---------- */
.hero{
  max-width:var(--maxw);margin:0 auto;
  padding:clamp(70px,12vw,140px) 24px clamp(60px,9vw,110px);
  text-align:center;position:relative;
}
.eyebrow{
  font-family:'JetBrains Mono',monospace;font-size:.78rem;letter-spacing:.18em;
  text-transform:uppercase;color:var(--teal);margin-bottom:26px;
}
.hero h1{
  font-family:'Fraunces',serif;font-weight:500;
  font-size:clamp(2.1rem,5.6vw,4.1rem);
  line-height:1.06;letter-spacing:-.02em;margin-bottom:28px;
}
.grad{
  background:var(--grad);-webkit-background-clip:text;background-clip:text;
  -webkit-text-fill-color:transparent;
}
.lede{
  max-width:720px;margin:0 auto 38px;font-size:clamp(1.02rem,1.6vw,1.18rem);
  color:var(--ink-soft);
}
.hero-cta{display:flex;gap:14px;justify-content:center;flex-wrap:wrap;margin-bottom:64px}
.btn{
  display:inline-flex;align-items:center;justify-content:center;gap:8px;
  padding:14px 26px;border-radius:12px;font-weight:600;font-size:.97rem;
  cursor:pointer;transition:transform .2s,box-shadow .2s,background .2s,border-color .2s;
  border:1px solid transparent;
}
.btn-primary{background:var(--grad);color:#06101e;box-shadow:0 14px 36px -14px var(--blue)}
.btn-primary:hover{transform:translateY(-2px);box-shadow:0 20px 46px -14px var(--blue)}
.btn-ghost{border-color:var(--line-strong);color:var(--ink-soft)}
.btn-ghost:hover{color:var(--ink);border-color:var(--blue);background:rgba(91,140,255,.08)}
.btn.full{width:100%;margin-top:8px}

.hero-stats{
  display:flex;gap:20px;justify-content:center;flex-wrap:wrap;
  max-width:760px;margin:0 auto;
}
.stat{
  flex:1;min-width:180px;padding:22px;border-radius:var(--r);
  background:rgba(17,26,44,.6);border:1px solid var(--line);
  backdrop-filter:blur(6px);
}
.stat-n{display:block;font-family:'Fraunces',serif;font-size:1.9rem;color:var(--ink);line-height:1}
.stat-l{display:block;margin-top:8px;font-size:.84rem;color:var(--ink-dim)}

.hero-scroll{
  margin-top:60px;font-size:.78rem;letter-spacing:.2em;text-transform:uppercase;
  color:var(--ink-dim);display:flex;flex-direction:column;align-items:center;gap:10px;
}
.hero-scroll span{
  width:1px;height:42px;background:linear-gradient(var(--blue),transparent);
  animation:scrolldot 2s infinite;
}
@keyframes scrolldot{0%{opacity:0;transform:translateY(-8px)}50%{opacity:1}100%{opacity:0;transform:translateY(8px)}}

/* ---------- ALERT BAND ---------- */
.band-alert{max-width:var(--maxw);margin:0 auto;padding:0 24px}
.alert-card{
  display:flex;gap:22px;align-items:flex-start;
  padding:30px 34px;border-radius:var(--r);
  background:linear-gradient(135deg,rgba(245,196,81,.1),rgba(245,196,81,.02));
  border:1px solid rgba(245,196,81,.3);
  box-shadow:var(--shadow);
}
.alert-icon{
  flex:none;width:42px;height:42px;border-radius:12px;
  display:grid;place-items:center;font-weight:700;font-size:1.4rem;
  background:rgba(245,196,81,.16);color:var(--amber);border:1px solid rgba(245,196,81,.4);
}
.alert-card h2{font-size:1.18rem;margin-bottom:8px;color:var(--amber)}
.alert-card p{color:var(--ink-soft);font-size:1rem}

/* ---------- SECTIONS ---------- */
.section{max-width:var(--maxw);margin:0 auto;padding:clamp(70px,10vw,120px) 24px}
.section-alt{
  max-width:none;margin:clamp(40px,7vw,90px) 0;
  background:
    radial-gradient(1200px 500px at 50% -10%,rgba(91,140,255,.07),transparent),
    var(--bg-alt);
  border-top:1px solid var(--line);border-bottom:1px solid var(--line);
}
.section-alt > *{max-width:var(--maxw);margin-left:auto;margin-right:auto}
.section-head{max-width:760px;margin:0 auto clamp(40px,5vw,60px);text-align:center}
.kicker{
  font-family:'JetBrains Mono',monospace;font-size:.76rem;letter-spacing:.16em;
  text-transform:uppercase;color:var(--teal);margin-bottom:16px;
}
.section-head h2{
  font-family:'Fraunces',serif;font-weight:500;
  font-size:clamp(1.7rem,3.6vw,2.6rem);line-height:1.12;letter-spacing:-.015em;
}
.section-sub{margin-top:18px;color:var(--ink-soft);font-size:1.05rem}

/* ---------- BIOMOL GRID ---------- */
.biomol-grid{display:grid;grid-template-columns:repeat(4,1fr);gap:18px}
.biomol{
  padding:28px 24px;border-radius:var(--r);text-align:center;
  background:var(--panel);border:1px solid var(--line);
  transition:transform .25s,border-color .25s;
}
.biomol:hover{transform:translateY(-4px);border-color:var(--line-strong)}
.biomol-ico{font-size:2rem;display:block;margin-bottom:14px}
.biomol h3{font-size:1.05rem;margin-bottom:8px}
.biomol p{font-size:.9rem;color:var(--ink-dim)}

/* ---------- CARDS ---------- */
.cards{display:grid;grid-template-columns:repeat(3,1fr);gap:22px}
.card{
  padding:30px 28px;border-radius:var(--r);
  background:linear-gradient(180deg,var(--panel),var(--bg-soft));
  border:1px solid var(--line);position:relative;overflow:hidden;
  transition:transform .25s,border-color .25s;
}
.card::before{
  content:"";position:absolute;left:0;top:0;width:100%;height:3px;
  background:var(--grad);transform:scaleX(0);transform-origin:left;transition:transform .35s;
}
.card:hover{transform:translateY(-5px);border-color:var(--line-strong)}
.card:hover::before{transform:scaleX(1)}
.card-top{display:flex;align-items:center;justify-content:space-between;margin-bottom:16px}
.card-num{font-family:'Fraunces',serif;font-size:1.6rem;color:var(--ink-dim)}
.card-tag{
  font-size:.72rem;letter-spacing:.08em;text-transform:uppercase;
  padding:5px 11px;border-radius:999px;color:var(--teal);
  background:rgba(47,214,196,.1);border:1px solid rgba(47,214,196,.25);
}
.card h3{font-size:1.18rem;margin-bottom:12px;letter-spacing:-.01em}
.card p{font-size:.94rem;color:var(--ink-soft)}

/* ---------- SCOPE NOTE ---------- */
.scope-note{
  display:flex;gap:18px;align-items:flex-start;
  margin-top:30px;padding:22px 26px;border-radius:var(--r);
  background:linear-gradient(135deg,rgba(47,214,196,.09),rgba(91,140,255,.04));
  border:1px solid rgba(47,214,196,.28);
}
.scope-ico{
  flex:none;width:38px;height:38px;border-radius:11px;display:grid;place-items:center;
  font-size:1.25rem;font-weight:700;color:var(--teal);
  background:rgba(47,214,196,.14);border:1px solid rgba(47,214,196,.35);
}
.scope-note p{font-size:.97rem;color:var(--ink-soft)}

/* ---------- PATHWAYS / TERAPIA DIRIGIDA ---------- */
.pathways{display:flex;flex-direction:column;gap:16px}
.pathway{
  padding:26px 30px;border-radius:var(--r);
  background:linear-gradient(180deg,var(--panel),var(--bg-soft));
  border:1px solid var(--line);border-left:3px solid transparent;
  border-image:linear-gradient(180deg,var(--teal),var(--blue),var(--violet)) 1;
  transition:transform .2s;
}
.pathway:hover{transform:translateX(4px)}
.pathway-head{display:flex;align-items:baseline;gap:16px;margin-bottom:14px}
.pathway-num{font-family:'Fraunces',serif;font-size:1.4rem;color:var(--ink-dim);flex:none}
.pathway-head h3{font-size:1.18rem;letter-spacing:-.01em}
.drug-chips{display:flex;flex-wrap:wrap;gap:8px;margin-bottom:14px}
.drug-chips span{
  font-family:'JetBrains Mono',monospace;font-size:.76rem;letter-spacing:.02em;
  padding:5px 11px;border-radius:999px;color:var(--blue);
  background:rgba(91,140,255,.1);border:1px solid rgba(91,140,255,.25);
}
.pathway p{font-size:.95rem;color:var(--ink-soft)}
.pathway-limit{
  display:flex;gap:18px;align-items:flex-start;margin-top:22px;
  padding:20px 26px;border-radius:var(--r);
  background:linear-gradient(135deg,rgba(245,196,81,.08),rgba(245,196,81,.02));
  border:1px solid rgba(245,196,81,.26);
}
.pathway-limit .alert-icon{width:34px;height:34px;font-size:1.15rem}
.pathway-limit p{font-size:.92rem;color:var(--ink-soft)}

/* ---------- LIMITS ---------- */
.limits{display:grid;grid-template-columns:repeat(4,1fr);gap:18px}
.limit{
  padding:26px 22px;border-radius:var(--r);
  background:var(--panel);border:1px solid var(--line);border-left:3px solid var(--violet);
}
.limit h3{font-size:1.02rem;margin-bottom:10px;color:var(--violet)}
.limit p{font-size:.9rem;color:var(--ink-soft)}

/* ---------- EN USO ---------- */
.usage-stats{
  display:grid;grid-template-columns:repeat(4,1fr);gap:16px;margin-bottom:40px;
}
.ustat{
  padding:20px;border-radius:var(--r);text-align:center;
  background:var(--panel);border:1px solid var(--line);
}
.ustat-n{display:block;font-family:'Fraunces',serif;font-size:1.7rem;
  background:var(--grad);-webkit-background-clip:text;background-clip:text;-webkit-text-fill-color:transparent;line-height:1}
.ustat-l{display:block;margin-top:8px;font-size:.82rem;color:var(--ink-dim)}

.usage-cols{display:grid;grid-template-columns:1fr 1fr;gap:24px}
.usage-h{
  display:flex;align-items:center;gap:10px;font-size:1.15rem;margin-bottom:18px;
  padding-bottom:12px;border-bottom:1px solid var(--line);
}
.flag{font-size:1.3rem}
.ucard{
  padding:24px;border-radius:var(--r);margin-bottom:16px;
  background:linear-gradient(180deg,var(--panel),var(--bg-soft));border:1px solid var(--line);
  transition:border-color .2s,transform .2s;
}
.ucard:hover{border-color:var(--line-strong);transform:translateY(-3px)}
.ucard-org{
  display:block;font-family:'JetBrains Mono',monospace;font-size:.74rem;letter-spacing:.04em;
  text-transform:uppercase;color:var(--teal);margin-bottom:10px;
}
.ucard p{font-size:.93rem;color:var(--ink-soft);margin-bottom:12px}
.ucard a{font-size:.86rem;color:var(--blue);font-weight:500;word-break:break-word}
.ucard a:hover{text-decoration:underline}
.ucard-note{
  display:block;margin-top:12px;padding-top:12px;border-top:1px dashed var(--line-strong);
  font-size:.8rem;color:var(--ink-dim);font-style:italic;
}
.usage-disclaimer{
  margin-top:30px;text-align:center;font-size:.88rem;color:var(--ink-dim);
  max-width:760px;margin-left:auto;margin-right:auto;
}

/* ---------- ACCESS ---------- */
.access{display:grid;grid-template-columns:1.25fr 1fr 1fr;gap:22px;align-items:start}
.access-card{
  padding:30px 28px;border-radius:var(--r);
  background:var(--panel);border:1px solid var(--line);position:relative;
}
.access-card.recommended{
  background:linear-gradient(180deg,rgba(47,214,196,.08),var(--panel));
  border-color:rgba(47,214,196,.35);
  box-shadow:0 24px 60px -30px rgba(47,214,196,.5);
}
.access-badge{
  position:absolute;top:-12px;left:28px;
  font-size:.72rem;font-weight:600;letter-spacing:.04em;
  padding:6px 14px;border-radius:999px;color:#06101e;background:var(--teal);
}
.access-card h3{font-size:1.22rem;margin-bottom:12px;letter-spacing:-.01em}
.access-card h3 .muted{color:var(--ink-dim);font-weight:400}
.access-lead{font-size:.92rem;color:var(--ink-soft);margin-bottom:20px}
.kv{list-style:none;display:flex;flex-direction:column;gap:0}
.kv li{
  display:flex;flex-direction:column;gap:3px;padding:12px 0;
  border-top:1px solid var(--line);
}
.kv li:first-child{border-top:0}
.kv span{font-size:.74rem;letter-spacing:.06em;text-transform:uppercase;color:var(--ink-dim)}
.kv strong{font-size:.92rem;font-weight:500;color:var(--ink)}
.access-steps{margin-top:20px;padding-top:18px;border-top:1px dashed var(--line-strong)}
.steps-title{font-size:.8rem;text-transform:uppercase;letter-spacing:.06em;color:var(--ink-dim);margin-bottom:10px}
.access-steps ol{margin-left:18px;display:flex;flex-direction:column;gap:8px}
.access-steps li{font-size:.9rem;color:var(--ink-soft)}

.reco{
  margin-top:40px;padding:34px 36px;border-radius:var(--r);
  background:linear-gradient(135deg,rgba(91,140,255,.1),rgba(167,139,250,.06));
  border:1px solid var(--line-strong);
}
.reco h3{font-family:'Fraunces',serif;font-weight:500;font-size:1.35rem;margin-bottom:12px}
.reco p{color:var(--ink-soft)}

/* ---------- REFS ---------- */
.refs{list-style:none;display:grid;grid-template-columns:repeat(2,1fr);gap:18px}
.refs li{
  padding:24px;border-radius:var(--r);background:var(--panel);border:1px solid var(--line);
  transition:border-color .2s;
}
.refs li:first-child{grid-column:1 / -1}
.refs li:hover{border-color:var(--line-strong)}
.ref-type{
  display:inline-block;font-family:'JetBrains Mono',monospace;font-size:.72rem;
  letter-spacing:.08em;text-transform:uppercase;color:var(--teal);margin-bottom:10px;
}
.refs p{font-size:.95rem;color:var(--ink-soft);margin-bottom:10px}
.refs a{font-size:.9rem;color:var(--blue);font-weight:500;word-break:break-word}
.refs a:hover{text-decoration:underline}

/* ---------- FOOTER ---------- */
.site-footer{border-top:1px solid var(--line);background:var(--bg-soft);margin-top:40px}
.footer-inner{max-width:var(--maxw);margin:0 auto;padding:44px 24px;text-align:center}
.footer-note{font-size:.9rem;color:var(--ink-dim);max-width:780px;margin:0 auto 14px}
.footer-meta{font-size:.8rem;color:var(--ink-dim);opacity:.7}

/* ---------- REVEAL ---------- */
.reveal{opacity:0;transform:translateY(26px);transition:opacity .7s ease,transform .7s ease}
.reveal.in{opacity:1;transform:none}

/* ---------- RESPONSIVE ---------- */
@media(max-width:980px){
  .biomol-grid,.limits{grid-template-columns:repeat(2,1fr)}
  .cards{grid-template-columns:repeat(2,1fr)}
  .usage-stats{grid-template-columns:repeat(2,1fr)}
  .usage-cols{grid-template-columns:1fr}
  .access{grid-template-columns:1fr}
  .refs{grid-template-columns:1fr}
  .refs li:first-child{grid-column:auto}
}
@media(max-width:680px){
  .nav-links{
    position:absolute;top:100%;left:0;right:0;flex-direction:column;gap:0;
    background:rgba(8,13,24,.97);border-bottom:1px solid var(--line);
    padding:8px 16px 16px;display:none;backdrop-filter:blur(14px);
  }
  .nav-links.open{display:flex}
  .nav-links a{display:block;padding:12px 8px}
  .nav-toggle{display:flex}
  .biomol-grid,.cards,.limits{grid-template-columns:1fr}
  .hero-stats{flex-direction:column}
  .alert-card{flex-direction:column;gap:14px;padding:24px}
}
@media(prefers-reduced-motion:reduce){
  *{animation:none!important}
  .reveal{opacity:1;transform:none;transition:none}
  html{scroll-behavior:auto}
}